Stimulation of lipolysis and cyclic amp accumulation in rabbit fat cells by human growth hormone*

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Summary

Human growth hormone (HGH) has been found to produce a rapid stimulation of lipolysis in isolated rabbit fat cells but not in rat adipocytes. The species specificity exhibited by HGH and other evidence strongly suggest that the lipolytic action is an intrinsic property of HGH and not due to contamination with other pituitary lipolytic agents. The stimulation of lipolysis by HGH appears to be mediated by cyclic AMP since the effect of the hormone on both cyclic AMP accumulation and glycerol release are potentiated by theophylline.

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*

Paper 34 in the Human Pituitary Growth Hormone series.

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