Serum Cefazolin Levels during Cardiopulmonary Bypass
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Cited by (19)
Perioperative Cefazolin Prophylaxis in Pediatric Cardiac Surgery: A Prospective, Cohort Study
2022, Annals of Thoracic SurgeryCitation Excerpt :This is likely related to our protocol of routine redosing for procedures every 3 hours. This finding contrasts with the results of other studies whereby procedures with longer CPB times were more likely to result in suboptimal therapeutic dosing.11,13,20 Further work is needed to examine the impact of prolonged procedures on the concentration of antimicrobial agents.
Pharmacokinetic characteristics and microbiologic appropriateness of cefazolin for perioperative antibiotic prophylaxis in elective cardiac surgery
2016, Journal of Thoracic and Cardiovascular SurgeryCitation Excerpt :In a short period of time between sampling points 2 and 3 (median span of 10 minutes [range, 4-30 minutes]), drug concentration dropped significantly. This finding resembles previously published results.12,14,17 In pharmacokinetic terms, this drop reflects an increase in the volume of distribution of cefazolin.
Cefazolin prophylaxis during cardiac operations [3] (multiple letters)
2004, Annals of Thoracic SurgerySerum levels of prophylactic cefazolin during cardiopulmonary bypass surgery
2002, Annals of Thoracic SurgeryVancomycin sequestration during cardiopulmonary bypass surgery
2002, Journal of InfectionCefazolin and netilmicin serum levels during and after cardiac surgery with cardiopulmonary bypass
1990, Journal of Cardiothoracic Anesthesia
Supported in part by a grant from the Eli Lilly Co.
Copyright © 1980 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.