Elsevier

Fertility and Sterility

Volume 94, Issue 4, September 2010, Pages 1560-1563
Fertility and Sterility

Correspondence
Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis

https://doi.org/10.1016/j.fertnstert.2009.12.024Get rights and content
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In this case-control study, we investigated the potential associations of MMP-2 and MMP-9 gene promoter region polymorphisms as well as MMP-2 promoter haplotypes with susceptibility to endometriosis in women of caucasian origin. The results demonstrated that polymorphisms in MMP-2 (−735 C/T) and MMP-9 (−1562 C/T) were associated with elevated risk of endometriosis and that certain MMP-2 promoter haplotypes were more common in control group.

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M.S. has nothing to disclose. M.L. has nothing to disclose. T.K. has nothing to disclose. H.K. has nothing to disclose. U.K. has nothing to disclose. A.M. has nothing to disclose. M.P. has nothing to disclose. A.S. has nothing to disclose.

Supported by the European Union via the European Regional Development Fund and the Center of Excellence in Genomics, Estonian Biocenter and University of Tartu, by the Estonian Science Foundation (grant nos 6498 and 6585), and by the Estonian Ministry of Education and Science (core grants nos 0180044s09, 0180142s08, and PBGMR07903).