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Association between dopamine receptor D3 gene BalI polymorphism and cognitive impulsiveness in alcohol-dependent men

Published online by Cambridge University Press:  16 April 2020

F. Limosin ,
L. Romo ,
P. Batel ,
J. Adès ,
C. Boni  and
Ph. Gorwood
F. Limosin
Affiliation:
Service de Psychiatrie Adulte, Faculty of medicine Bichat-Claude Bernard, Louis Mourier hospital (AP-HP), 178, rue des Renouillers, 92701Colombes cedex, France Department of Psychiatry, Albert Chenevier Hospital, Créteil, France
L. Romo
Affiliation:
Service de Psychiatrie Adulte, Faculty of medicine Bichat-Claude Bernard, Louis Mourier hospital (AP-HP), 178, rue des Renouillers, 92701Colombes cedex, France
P. Batel
Affiliation:
Hôpital Beaujon (AP-HP), UTAMA, 92110Clichy, France Inserm U675 (IFR2, Faculty Bichat), 16, rue Henri Huchard, 75018Paris, France
J. Adès
Affiliation:
Service de Psychiatrie Adulte, Faculty of medicine Bichat-Claude Bernard, Louis Mourier hospital (AP-HP), 178, rue des Renouillers, 92701Colombes cedex, France Inserm U675 (IFR2, Faculty Bichat), 16, rue Henri Huchard, 75018Paris, France
C. Boni
Affiliation:
Inserm U675 (IFR2, Faculty Bichat), 16, rue Henri Huchard, 75018Paris, France
Ph. Gorwood*
Affiliation:
Service de Psychiatrie Adulte, Faculty of medicine Bichat-Claude Bernard, Louis Mourier hospital (AP-HP), 178, rue des Renouillers, 92701Colombes cedex, France Inserm U675 (IFR2, Faculty Bichat), 16, rue Henri Huchard, 75018Paris, France
*
*Corresponding author. Tel.: +33 1 47 60 64 16; fax: +33 1 47 60 67 40. E-mail address: philip.gorwood@lmr.aphp.fr (Ph. Gorwood).
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Abstract

The gene coding for the dopamine receptor D3 (DRD3) is considered as a major candidate gene in various addictive disorders. Association studies in alcohol-dependence for this gene are nevertheless controversial. We made the hypothesis that phenotypical heterogeneity of alcohol-dependence (i.e. the DRD3 gene is a vulnerability gene in a specific subgroup of patients only) could explain these spurious findings, focusing on a core dimension of addictive disorders, namely impulsiveness. In our sample of 108 French alcohol-dependent patients, patients above the median value for cognitive impulsiveness (one of the three dimensions of the Barratt scale) were more frequently heterozygous than both alcohol-dependent patients with lower impulsiveness (OR = 2.51, P = 0.019) and than 71 healthy controls (OR = 2.32, P = 0.025). Age at interview, antisocial personality disorder, other comorbid addictive disorder, age at onset of alcohol-dependence, and lifetime mood disorders did not constitute confusing intermediate factors.

Keywords

GeneticsAddictionTemperamentHeterogeneity
Type
Rapid communication
Information
European Psychiatry , Volume 20 , Issue 3 , May 2005 , pp. 304 - 306
Copyright
Copyright © Elsevier SAS 2005

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