Cancer Cell
Volume 37, Issue 4, 13 April 2020, Pages 485-495
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Review
Liquid Biopsy-Based Biomarkers of Treatment Response and Resistance

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Predictive biomarkers aid selection of personalized therapy targeted to molecular alterations within an individual's tumor. Patients' responses to targeted therapies are commonly followed by treatment resistance. Here, we survey liquid biopsies as alternatives to tumor biopsies to assess predictive and therapy response biomarkers. We examine the potential of liquid biopsies to meet the challenges of minimal residual disease monitoring after curative intent treatment for earlier detection of disease recurrence. We focus on blood, the most commonly collected minimally invasive clinical sample, and on the two most widely studied assays, circulating tumor DNA and circulating tumor cells.

Key Words

personalized cancer medicine
liquid biopsy
circulating tumor DNA
circulating tumor cells
predictive biomarkers
treatment response biomarkers
minimal residual disease monitoring
targeted and immunotherapy
sensitivity and specificity
treatment resistance

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