Chapter 2 - AMPK: the energy sensor that regulates autophagy and a potential therapeutic target for neurodegenerative diseases
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Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner
2021, Developmental CellCitation Excerpt :Expansion and closure of this structure results in a vesicle known as the autophagosome. Autophagosome biogenesis is induced as a response to various stimuli, including nutrient starvation, leading to the inhibition of the negative autophagy regulator mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) and the activation of AMP-activated protein kinase (AMPK) (Karabiyik et al., 2021). This results in the activation of two distinct kinase complexes that initiate phagophore biogenesis—the ULK1 complex and the phosphatidylinositol 3-kinase (PI3K) complex.
Autophagy Mechanisms for Brain Recovery. Keep It Clean, Keep It Alive
2023, Contemporary Clinical Neuroscience
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