Handbook of Chitin and Chitosan

Handbook of Chitin and Chitosan

Volume 1: Preparation and Properties
2020, Pages 59-100
Handbook of Chitin and Chitosan

Chapter 3 - PEGylated chitin and chitosan derivatives

https://doi.org/10.1016/B978-0-12-817970-3.00003-1Get rights and content

Abstract

Chitin and chitosan are some of the most naturally abundant biopolymers. Their applications range from biomedical to adsorption of dye and heavy metals. But due to their immiscibility in water and other most commonly used organic solvents their application is limited. PEGylated chitin/chitosan derivatives can mitigate that problem as they enhance the solubility. In addition to improving solubility, PEGylated chitin/chitosan derivatives have lower cytotoxicity, higher ductility, and high stability in body fluids, which enable them to be applied in highly efficient drug delivery, gene delivery, stimuli responsive hydrogel formation, and nanofiber formation. This chapter discusses the synthesis process, characterization, and application of PEGylated chitin/chitosan derivatives.

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