Distribution of viral RNA molecules during the adenovirus type 5 infectious cycle in HeLa cells☆
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Nuclear actin and myosins in adenovirus infection
2015, Experimental Cell ResearchThe role of Cajal bodies in the expression of late phase adenovirus proteins
2010, VirologyCitation Excerpt :Transcription sites overlap the replication foci but extend further into the nucleoplasm away from E2A-72K domains, forming patterns of inter-connecting rings (Pombo et al., 1994). The transcription zones also contain nascent viral RNA (Pombo et al., 1994; Puvion-Dutilleul and Puvion, 1992), splicing snRNPs (Aspegren and Bridge, 2002), viral introns and exons (Rebelo et al., 1996; Aspegren et al., 1998; Bridge et al., 1996). The transition from the early to the late phase requires viral gene expression from replicated templates (Chalberg and Kelley, 1989).
An early function of the adenoviral E1B 55 kDa protein is required for the nuclear relocalization of the cellular p53 protein in adenovirus-infected normal human cells
2008, VirologyCitation Excerpt :Moreover, the E1B 55 kDa and E4 Orf6 proteins form a complex that can associate with cellular proteins to form an infected cell-specific, cullin5-containing E3 ubiquitin ligase that polyubiquitinylates and stimulates proteasomal degradation of p53 (Harada et al., 2002; Querido et al., 2001; Sarnow et al., 1984; Woo and Berk, 2007). In infected cell nuclei, the E1B 55 kDa and E4 Orf6 proteins colocalize to the peripheral zones of specific nuclear microenvironments where viral DNA replication, transcription of viral late genes and the initial posttranscriptional processing of viral late mRNAs take place (Aspegren et al., 1998; Bridge et al., 1995; Ornelles and Shenk, 1991; Pombo et al., 1994; Puvion-Dutilleul et al., 1992). Mutations that reduce binding of the E1B 55 kDa (E1B) to the E4 Orf6 protein result in altered localization of E1B, and inefficient export of viral late mRNAs (Gonzalez and Flint, 2002; Ornelles and Shenk, 1991; Rubenwolf et al., 1997), correlating efficient viral late mRNA export with the organization of infected cell nuclei.
A Guide to Viral Inclusions, Membrane Rearrangements, Factories, and Viroplasm Produced During Virus Replication
2007, Advances in Virus ResearchRelease of snRNP and RNA from transcription sites in adenovirus-infected cells
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This work was supported by general grants from the Centre National de la Recherche Scientifique and special grants from the Association pour la Recherche sur le Cancer (Villejuif/France) and the Fondation pour la Recherche Médicale.
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F. Puvion-Dutilleul is a member of the Institut National de la Santé et de la Recherche médicale.
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Present address: Institute of General and Comparative Pathology, Bulgarian Academy of Sciences, Acad. G. Bonchev, Str. Bl. 25, Sofia 1113, Bulgaria.