Short sequence-paper
Cloning and sequence analysis of caprine N-acetylglucosamine 6-sulfatase cDNA

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Abstract

Mucopolysaccharidosis BID results from the deficiency of N-acetylglucosamine 6-sulfatase activity. A Nubian goat with this lysosomal storage disease has been identified. As a first step in developing this animal model for testing treatment methods, we cloned and sequenced the capfne N-acetylglucosamine 6-sulfatase cDNA coding region. Overall there is 88% nucleotide homology between the goat and human sequence and 94% homology of the deduced amino acid sequence. The human and two ruminant species differ by the presence of an imperfect trinucleotide (CCG) repeat in the ruminant signal sequence.

Keywords

Caprine
N-Acetylglucosamine 6-sulfatase
cDNA
Mucopolysaccharidosis IIID
Comparative genomics
Trinucleetide repeat
(Human)

Cited by (0)

The sequence data reported in this paper have been submitted to the EMBL/GenBank Data Libraries under the accession number U17694.