European Journal of Pharmacology: Molecular Pharmacology
Regular paperSelective enrichment with α1A- and α1B-adrenoceptor subtypes in rat brain cortical membranes
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Search for influence of spatial properties on affinity at α<inf>1</inf>-adrenoceptor subtypes for phenylpiperazine derivatives of phenytoin
2010, Bioorganic and Medicinal Chemistry LettersComparison of the binding affinity of CGP-12177A at recombinant rat α<inf>1D</inf>-adrenoceptors expressed in BHK-21 cell membranes and α<inf>1</inf>-adrenoceptors present in rat cerebral cortex membranes
2008, European Journal of PharmacologyCitation Excerpt :A common feature of these reports, however, is that the measurements of the binding affinity of CGP-12177A at α1-adrenoceptors was always performed in rat cerebral cortex membranes, because of the low amount of tissue provided by the vessels (Brahmadevara et al., 2004). But, in rat cerebral cortex α1A- and α1B-adrenoceptors are predominant (Salles and Badia, 1994), whereas α1D-adrenoceptor is the most represented subtype in rat aorta and mesenteric arteries (Martì et al., 2005), where it regulates smooth muscle contraction (Piascik and Perez, 2001). Therefore, an important question arises about the possibility to compare binding affinity and functional affinity data, obtained from experiments carried out in different tissues where various α1-adrenoceptor subtypes are expressed.
Synthesis and α<inf>1</inf>-antagonist activity of new prazosin- and benextramine-related tetraamine disulfides
1997, European Journal of Medicinal Chemistry