Progression of renal insufficiency in analgesic nephropathy: Impact of continuous drug abuse

doi:10.1016/0895-4356(91)90200-S

Journal of Clinical Epidemiology

Volume 44, Issue 1, 1991, Pages 53-56

https://doi.org/10.1016/0895-4356(91)90200-S Get rights and content

Abstract

Twenty-three patients with analgesic nephropathy and apparent cessation of drug abuse were tested for blood acetaminophen and salicylate on the occasion of routine renal control examinations. In 12 patients (mean creatinine level 2.74 ± 1.09 mg/dl) no deterioration of renal function was noted within a 1-year observation period (Group 1). In 11 patients a significant progression of renal insufficiency was observed (mean creatinine level rose from 3.86 ± 1.06 to 6.40±3.18 mg/dl within the same observation period; Group 2). Blood tests for acetaminophen and salicylate were positive in 2 patients of Group 1 and in 9 patients of Group 2(ξ² = 7.326), p < 0.01). Our data emphasize the importance of a continuous analgesic abuse hidden from the medical staff with regard to the progression of renal insufficiency in analgesic nephropathy.

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Progression of renal insufficiency in analgesic nephropathy: Impact of continuous drug abuse

Abstract

Kidney Int

Kidney Int

Analgesic nephropathy: a recoverable form of chronic renal failure

Epidemiology of analgesic associated nephropathy in North America

Epidemiology study of abuse of analgesics containing phenacetin: renal morbidity and mortality (1968–1979)

N Engl J Med

Chronic renal failure and end stage renal disease in Northwest North Carolina. Importance of analgesics-associated nephropathy

Arch Intern Med

On the prevalence of analgesic nephropathy in the Federal Republic of Germany in West Berlin

Epidemiology of analgesic nephropathy in Belgium

Clin Nephrol

Is analgesic nephropathy still a problem in Belgium?

Nephrol Dialysis Transplant

Analgesic use and chronic renal disease

N Engl J Med