ArticleThe effect of toluene on the vestibulo- and opto-oculomotor system in rats, pretreated with GABAergic drugs
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An in vitro model to assess the peripheral vestibulotoxicity of aromatic solvents
2021, NeuroToxicologyCitation Excerpt :In addition to impairing hearing, solvents have been shown to disrupt balance. Solvents have a negative impact on the sensory-motor integration of postural stability regulation and vestibular pathways (Calabrese et al., 1996; Niklasson et al., 1993; Tham et al., 1990). However, the precise mechanism through which aromatic solvents affect the vestibular system remains elusive.
The toxic effects of toluene on the optokinetic nystagmus in pigmented rats
2009, Ecotoxicology and Environmental SafetyA comparison of the acute neuroactive effects of dichloromethane, 1,3-dichloropropane, and 1,2-dichlorobenzene on rat flash evoked potentials (FEPs)
1997, Fundamental and Applied ToxicologyBalance system assessment in workers exposed to organic solvent mixture
2011, Journal of Occupational and Environmental MedicineCitation Excerpt :The vestibular hyporeactivity may be of peripheral or central origin. Tham et al2,3 suggested that toluene caused excitation of the VOR reflex by interacting with the central pathways in reticular formation and the cerebellum, which might result in nystagmus reduction. Unfortunately, fixation index-–the vulnerable tool to distinguish between peripheral and central abnormalities-–was not included in our protocol.