In vivo evaluation of indomethacin/ cyclodextrin complexes gastrointestinal tolerance and dermal anti-inflammatory activity

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Abstract

Inclusion complexes of indomethacin in β-cyclodextrin and hydroxypropyl-β-cyclodextrin were prepared and evaluated in vivo. With respect to the gastrointestinal tolerance assessed in the rat, it appears that the inclusion of indomethacin in these cyclodextrins results in a decrease in its irritation power, confirming that this undesirable effect has at least a local origin. With respect to the dermal anti-inflammatory activity assessed on healthy volunteers by the methyl nicotinate test, the results seem to demonstrate that inclusions in either of the cyclodextrins investigated have a higher activity than free indomethacin.

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