Research paperPermeability of prostaglandin F2α and prostaglandin F2α esters across cornea in vitro
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Molecular design for enhancement of ocular penetration
2008, Journal of Pharmaceutical SciencesCitation Excerpt :Ocular penetration of PGF2α is limited because it will exhibit an ionized form in tears at neutral pH due to the presence of the carboxylic acid functionality.94 Esterification of the carboxyl moiety at 1-position significantly increased the corneal permeability and the IOP lowering activity (Tab. 8).95–98 Since esters of PGF2α are metabolized to the free acid in the cornea, they act as prodrugs.
Iontophoresis: A non-invasive ocular drug delivery
2006, Journal of Controlled ReleaseMicrovascular effects of selective prostaglandin analogues in the eye with special reference to latanoprost and glaucoma treatment
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1997, Advanced Drug Delivery ReviewsOcular penetration and bioconversion of prostaglandin F(2α) prodrugs in rabbit cornea and conjunctiva
1997, Journal of Pharmaceutical Sciences
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