International Journal of Radiation Oncology*Biology*Physics
Original contributionThe implications of improved treatment of malignant salivary gland tumors by fast neutron radiotherapy☆
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Cited by (63)
The efficacy of neutron radiation therapy in treating salivary gland malignancies
2019, Oral OncologyCitation Excerpt :They found the highest relative biological difference (RBE) of 8 occurred for adenoid cystic carcinoma compared to 3–3.5 for most normal tissues. This discovery was followed by many nonrandomized neutron clinical trials that supported this conclusion [25,26]. Additional work has indicated that NRT has much higher linear energy transfer (LET) than conventional photon radiotherapy.
Salivary Gland Malignancies
2015, Clinical Radiation OncologyA rationale for chemoradiation (vs radiotherapy) in salivary gland cancers? On behalf of the REFCOR (French rare head and neck cancer network)
2014, Critical Reviews in Oncology/HematologyCitation Excerpt :The initial rationale was a reduced oxygen enhancement ratio, but the revised rationale suggests a higher relative biological effectiveness for slowly cycling tumors. While local control rates vary widely with photons and are generally poor, using neutrons in 213 patients, local control rates yielded 50% in squamous cell carcinomas and 80% in adenoid cystic carcinomas [33,50–52]. Battermann et al. indeed showed that the relative biological effect was highest for adenoid cystic carcinomas and reached 8 (i.e. neutrons were 8 times more efficient than photons for that histology) with fractionated neutron therapy [49].
Management of nasopharyngeal adenoid cystic carcinoma
2013, Journal of Oral and Maxillofacial SurgeryAdenoid cystic carcinoma of the head and neck
2012, American Journal of Otolaryngology - Head and Neck Medicine and SurgeryCitation Excerpt :The improvement in local control after combined modality therapy compared with RT alone is probably due to a combination of improved efficacy and selection bias. Neutron RT may be associated with an improved probability of local–regional control when compared with conventional megavoltage photon and/or electron beams because of a lower oxygen enhancement factor (OER), less repair of sublethal damage, and less variation of radiosensitivity through the cell cycle [4,24,25]. Thus, neutrons may be preferable to treat large, slow-growing, hypoxic tumors such as advanced ACCs.
Salivary Gland Malignancies
2012, Clinical Radiation Oncology: Third Edition
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Work carried out at MRC Cyclotron Unit, Hammersmith Hospital, Ducane Road, London W 12 OHS.