International Journal of Radiation Oncology*Biology*Physics
Original contributionThe relationship of time-dose fractionation factors to complications in the treatment of pituitary tumors by irradiation☆
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2019, Radiotherapy and OncologyCitation Excerpt :For 1.8 and 2.0 Gy fraction sizes at the optic pathway, equivalent maximum optic structure dose tolerances were calculated to be 57 Gy and 55 Gy, respectively. These dose tolerances are consistent with prior data [15–17,19], though the actuarial risk was much lower in our cohort. This may reflect higher doses per fraction and use of older imaging and treatment technologies in some of these studies, as well the more conformal radiation treatment achieved with protons in our study.
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2016, American Journal of Ophthalmology Case ReportsCitation Excerpt :Our case demonstrates the importance of considering not just the cumulative radiation dose that the optic nerves can tolerate but also the size of each fraction to minimize the risk of RON. Previous studies of external beam radiotherapy involving the anterior visual pathway have demonstrated that single doses of 1.9 Gy or less are typically safe.8–10 The single-dose tolerance with stereotactic radiosurgery is estimated to be 8–12 Gy.11–15
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This work was supported in part by: U.S. Federal Program Project Grant (Radiation Oncology, University of Arizona 5010-3131-15 from the National Cancer Institute (NCI) and National Cancer Institute Wisconsin Clinical Grant (CA-14520-02). Presented at the Annual Meeting of the American Society of Therapeutic Radiologists, 13–16 Oct. 1976, Atlanta, Georgia, U.S.A.