Differential distribution of immunoreactive angiotensin and angiotensin-converting enzyme in rat brain
References (39)
- et al.
Angidtensin-converting enzyme: presence of high-activity in choroid plexus of mammalian brain
Eur. J. Pharmac.
(1978) - et al.
Immunohistochemical evidence for the existence of angiotensin II—containing nerve terminals in the brain and spinal cord in the rat
Neuroscience Letters
(1976) - et al.
Renin-like immunocytochemical activity in the rat and mouse brain
Neuroscience Letters
(1980) - et al.
Two distinct enkphalinases: solubilization, partial purification and separation from angiotensin converting enzyme
Life Sci.
(1979) - et al.
Renin and proreinin in hog brain: ubiquitous distribution and high concentration in the pituitary and pineal
Brain Res.
(1980) - et al.
Endogenous angiotensin in brain
Prog. Brain Res.
(1977) - et al.
Angiotensin-converting enzyme activity in the choroid plexus and in the retina
- et al.
Substance P. degradation by rat brain peptidases: inhibition by SQ 20881
Biochem. Pharmac.
(1979) - et al.
An angiotensin-like peptide in the brain
Life Sci.
(1980) - et al.
Immunochemical comparison of angiotensin I-converting enzyme from different rat organs
Int. J. Biochem.
(1979)
The brain renin-angiotensions system: a re-evaluation
Neuroscience
Converting enzyme in the choroid plexus, brain, and kidney: immunocytochemical studies in rats
Neuroscience Letters
A critical review of immunocytochemical methods for light microscopy
J. Neurosci. Meth.
Radioantographic localization of specific sites for blood-borne angiotensin II in the rat brain
Brain Res.
Exploration peptidexic pathways in brain by immunocytochemistry: a ten year perspective
Peptides
Distribution of neurophysin, oxytoin and vasopressin in the rat
Ph.D. Thesis Dissertation Abstracts
Angiotensin-converting enzyme: vascular endothelial localization
Science, N.Y.
Angiotensin II immunohistochemistry of the rat brain
Neuroendocrinology
Pulmonary angiotensin-converting enzyme antienzyme antibody
Biochemistry
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Beneficial effects of Angiotensin II receptor blockers in brain disorders
2017, Pharmacological ResearchAnxiogenic-like effects induced by hemopressin in rats
2015, Pharmacology Biochemistry and BehaviorCitation Excerpt :In comparative analyses, using bradykinin as a standard substrate for these three enzymes, which was then considered 100% of relative ratio of hydrolysis in a given period of time at maximal enzymatic velocity, it was shown that HP is hydrolyzed 152.24% by EP24.16, 140% by EP24.15 and 1146.19% by ACE (Rioli et al., 2003). The presence of these peptidases in peripheral and brain tissue is well documented (Cicilini et al., 1977; Chevillard and Saavedra, 1982; Brownfield et al., 1982; Massarelli et al., 1999; Fontenele-Neto et al., 2001), suggesting that HP could be efficiently degraded following i.p. or I.C.V. administration. HP can be hydrolyzed by EP24.15 and/or EP24.16 in different peptide bonds to generate the N-terminal fragments PVNF, PVNFK and/or PVNFKF (Rioli et al., 2003).
Angiotensin II and CRF receptors in the central nucleus of the amygdala mediate hemodynamic response variability to cocaine in conscious rats
2010, Brain ResearchCitation Excerpt :Ang receptors in the CNS play an important role in autonomic and neurohumoral responses to behavioral and pharmacological stress (Jezova et al., 1998; Knuepfer et al., 2005; Rowe et al., 2006; Saiki et al., 1997). Ang and AT1 receptors exist in the amygdala and, in particular, in the CeA (Brownfield et al., 1982; von Bohlen und Halbach and Albrecht, 1998). Microinjection of Ang in the amygdala of the rat increases the discharge rate of amygdalar neurons and the increase can be blocked by either AT1 or AT2 receptor antagonists (Albrecht et al., 2000).
Angiotensin type-1-receptor antagonists reduce 6-hydroxydopamine toxicity for dopaminergic neurons
2007, Neurobiology of AgingCitation Excerpt :Furthermore, ACE occurs in neurons, and high concentrations of ACE have been observed in the striatum and substantia nigra of mammals including rats [14] and humans [13]. Immunohistochemical location of AII, as well as of AII-ir terminals, has been reported in the human and rat striatum [8,52]. AT1 receptors occur in DA neurons, both in cell bodies in the substantia nigra and their terminal fields in the striatum of different mammals, including rats and humans, as revealed by autoradiography [1,2,15,58] and subsequently confirmed by immunohistochemistry [4,54] and in situ hybridization histochemistry [38].
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Current address: Dr. M.S. Brownfield, Department of Anatomical and Physiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53715, U.S.A.