General paper
The relationship between erythrocyte superoxide dismutase activity and plasma levels of some trace elements (Al, Cu, Zn) of dialysis patients

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Abstract

  • 1.

    1. The effect of erythropoietin and some trace elements on superoxide dismutase (SOD) activity of dialysis patients have been studied.

  • 2.

    2. SOD activity of dialysis patients was found to be decreased.

  • 3.

    3. The effect of erythropoietin on SOD activity was not found in vitro.

  • 4.

    4. Plasma and erythrocyte aluminum increased in dialysis patients, but no significant change in plasma copper was found.

  • 5.

    5. Plasma zinc levels of dialysis patients were found to be decreased.

  • 6.

    6. These results suggest that inhibition of erythrocyte SOD activity of dialysis patients may contribute to their anemia.

References (32)

  • M.R. Clemens et al.

    Some new aspects on free radical reaction in red cell pathology

  • A.J. Erslew

    Anemia of chronic renal disease

    Arch. Intern. Med.

    (1970)
  • J.W. Fisher et al.

    Role of erythropoietin and inhibitors of erythropoiesis in anemia of renal insufficiency

    Dialysis Transpl.

    (1978)
  • J.W. Fisher et al.

    Role of erythropoiesis in anemia of renal insufficiency

    Dialysis Transpl.

    (1978)
  • O. Giardini et al.

    Evidence of red blood cell membrane lipid peroxidation in haemodialysis patients

    Nephron

    (1984)
  • A.B. Gruskin et al.

    Aluminium intoxication in children

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      Citation Excerpt :

      Considering the importance of zinc as an essential trace element, little is known about zinc distributions in patients with CRF. Subnormal plasma zinc levels have been reported in these patients,5,7,18-21 but it is not clear whether a low concentration of plasma zinc is indicative of zinc deficiency in uremia because the zinc concentration of erythrocyte is frequently reported to be elevated.5,8,11,22 In the present study, we found the same condition.

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