General paper
Effects of chronic treatments with sm-9018, a potential atypical neuroleptic, on behavioral dopaminergic and serotonergic sensitivities in rats

https://doi.org/10.1016/0306-3623(94)00228-FGet rights and content

Abstract

  • 1.

    1. Changes in behavioral dopaminergic and serotonergic sensitivities were studied in rats after withdrawal of the chronic treatments with SM-9018 (0.1 mg/kg/day), a potential atypical neuroleptic, and with haloperidol (0.3 mg/kg/day) using continuous infusion pumps.

  • 2.

    2. Administration of SM-9018 inhibited the rat locomotor activities to an extent similar to that of haloperidol during the course of the 2 weeks treatment.

  • 3.

    3. The incidence of the apomorphine-induced stereotyped behaviors (e.g., sniffing, chewing, licking and biting) was negligibly affected by SM-9018 treatment, but was markedly enhanced by haloperidol treatment.

  • 4.

    4. The incidence of the 5-hydroxytryptophan-induced wet dog shakes and 8-hydroxy-2-(di-n-propyl-amino)tetralin-induced flat body posture was unaffected by either treatment with SM-9018 or haloperidol.

  • 5.

    5. These findings suggest that SM-9018 is weaker than haloperidol in inducing the behavioral dopaminergic hypersensitivity after its chronic treatment and has a lower propensity to cause tardive dyskinesia.

References (22)

  • E.J. Hess et al.

    Chronic treatment with dopamine receptor antagonists: Behavioral and pharmacologic effects on D1 and D2 dopamine receptors

    J. Neurosci.

    (1988)
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