Preliminary note
The formation of guanosine diphosphate-2-deoxy-d-glucose in yeast

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Cited by (33)

  • Cellular toxicity of the metabolic inhibitor 2-deoxyglucose and associated resistance mechanisms

    2020, Biochemical Pharmacology
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    Accordingly, a yeast-specific MAP kinase-based signaling pathway that responds to cell wall damage is activated in response to 2-DG treatment, suggesting that 2-DG triggers perceivable damage to the cell wall structure [71]. Proof of the existence of UDP-2-DG [72] and GDP-2-DG in 2-DG-treated yeast were later provided, suggesting interference with cell wall synthesis either through trapping of cellular uridine- or guanosine-nucleotide pools or by competitive inhibition with endogenous precursors [48,73]. Incorporation of 2-DG in storage carbohydrates, such as glycogen (both in vitro and in vivo) [74,75] or trehalose were also reported [41,76].

  • Hexokinase activity alters sugar-nucleotide formation in maize root homogenates

    2000, Phytochemistry
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    These data were taken as evidence that the sugar signalling is uncoupled from sugar metabolism in plants. However, the formation of 2-dG-containing oligosaccharides has been reported in plants (Barber, 1959; Fischer & Weidemann, 1966), bacteria (Krieglstein & Fischer, 1967), and yeast (Biely, Kratky & Bauer, 1971), and UDP-2-dG and GDP-2-dG have been identified as precursors in a variety of cells (Biely & Bauer, 1968; Schmidt, Schwarz & Scholtissek, 1974). These studies showed that 2-dG does not alter the glucosyl-transfer reactions.

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