A μ-receptor opioid agonist induces AP-1 and NF-κB transcription factor activity in primary cultures of rat cortical neurons
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Normalization of the H3K9me2/H3K14ac-ΔFosB pathway in the nucleus accumbens underlying the reversal of morphine-induced behavioural and synaptic plasticity by Compound 511
2023, PhytomedicineCitation Excerpt :In the current work, we focused on how Compound 511 alters the molecular basis of CPP reinstatement in the NAc to blunt its expression. The activation of several transcription factors in the NAc, including CREB (Barrot et al., 2002; Lai et al., 2014; Walters and Blendy, 2001), ΔFosB (Chen et al., 1997; Lobo et al., 2013; Solecki et al., 2008; Zachariou et al., 2006), and NF-kB (Hou et al., 1996; Nennig and Schank, 2017), are critical for the long-lasting alterations to transcriptional activity in genes associated with synaptic plasticity following chronic morphine treatment. The persistence of alterations to transcriptional activity and cellular physiology is partly mediated by histone modifications (Browne et al., 2020).
Transcriptional Alterations in Dorsolateral Prefrontal Cortex and Nucleus Accumbens Implicate Neuroinflammation and Synaptic Remodeling in Opioid Use Disorder
2021, Biological PsychiatryCitation Excerpt :On activation, NFκB dimers translocate to the nucleus to drive transcription of cytokines, chemokines, and interleukins (74,75). In addition, opioids can activate NFκB via opioid receptors (77–81), and activation of NFκB signaling can, in turn, promote transcription of opioid receptors and peptides (82–87) involved in opioid reward (82,88,89). Thus, while opioids can influence immune function via NFκB, opioids may also activate NFκB, with downstream effects on addiction-related behaviors, independent of immune function.
Opioid receptor modulation of neural circuits in depression: What can be learned from preclinical data?
2020, Neuroscience and Biobehavioral ReviewsCitation Excerpt :AP-1, like CREB, is upstream of genes associated with neuroplasticity, and AP-1 binding motifs are present in the promoter regions of endogenous opioid sequences (Naranjo et al., 1991; Sonnenberg et al., 1989; Therrien and Drouin, 1991). in vitro, MOR agonists induce AP-1 activity and c-Fos and JunB mRNA expression (Bilecki et al., 2004; Hou et al., 1996; Shoda et al., 2001), which is blocked by MAPK inhibitors (Shoda et al., 2001), suggesting that activation of MAPK pathways is responsible for AP-1 activity. in vivo, acute morphine administration induces c-Fos and JunB in the caudate putamen, paraventricular nucleus of the hypothalamus, and parts of the cortex, whereas c-Fos is additionally induced in NAc and thalamus (Garcia et al., 1995; Laorden et al., 2000).
Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR
2015, VirologyCitation Excerpt :MSK enzymes phosphorylate several protein targets including histones, cyclic AMP-responsive element binding protein (CREB), ATF1, NF- ĸB, as well as various AP-1 subunits, such as c-fos and c-jun (Dunn et al., 2005; Panneer et al., 2014; Soloaga et al., 2003; Vermeulen et al., 2003). In the context of cocaine, previous studies in a mouse model have shown a role for MSK1 in the activation of the immediate early gene, c-fos, and the extracellular signal-regulated kinase (ERK) signaling pathway in the striatum following cocaine exposure (Ang et al., 2001; Brami-Cherrier et al., 2005; Dhillon et al., 2007; Hou et al., 1996; Nowak and Corces, 2004; Yao et al., 2010). However, its role in human cells and how MSK1 influences HIV-1 transcription have never been investigated.
Opioid and nociceptin receptors regulate cytokine and cytokine receptor expression
2008, Cellular ImmunologyCitation Excerpt :Although the biochemical basis for this effect remains uncertain, however, there are published results which suggest a possible molecular mechanism. An examination of the MOR signal transduction pathway shows that MOR activation results in an increase in the activity and DNA-binding activity of the transcription factors Nuclear Factor-κB (NF-κB) and AP-1 in primary neurons [78]. Bilecki et al. [79] reported that stimulation of MOR resulted in the increased phosphorylation and activity of cAMP Response Element-Binding (CREB) transcription factor, as well as the increased activity and DNA-binding activity of AP-1 in the Neuro2aMOR neuronal cell line.
Action of NF-κB on the delta opioid receptor gene promoter
2007, Biochemical and Biophysical Research CommunicationsCitation Excerpt :NF-κB has been known to be involved in opioid functions in both immune and neuronal cells (reviewed in [12] and references cited therein). It has been documented that opioid treatment has the effect on NF-κB activity in neuronal cells [21]. Chronic opioid treatment resulted in inhibition of NF-κB signaling [22].