Increase in substance P and CGRP, but not somatostatin content of innervating dorsal root ganglia in adjuvant monoarthritis in the rat
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Changes in dorsal root ganglion CGRP expression in mouse pinch nerve injury model: Modulation by Somatostatin type-2 receptor
2022, Journal of Chemical NeuroanatomyInjury of primary afferent neurons may contribute to osteoarthritis induced pain: An experimental study using the collagenase model in rats
2015, Osteoarthritis and CartilageCitation Excerpt :A similar mechanism may occur in the MIA model. Articular inflammation is known to increase SP expression in the DRG42. We observed that collagenase-injected animals showed an overexpression of SP 1 week after collagenase injection, although it did not reach statistical significance.
Forced treadmill running suppresses postincisional pain and inhibits upregulation of substance P and cytokines in rat dorsal root ganglion
2014, Journal of PainCitation Excerpt :Experimental preliminary observations suggest that adrenalectomy prolongs the duration of swelling and potentiates both joint inflammation and the elevation of SP and CGRP in innervating DRG in adjuvant monoarthritis.41 Because substantial evidence suggest that more release of SP and CGRP—both centrally and peripherally—is proinflammatory, the “stress-like” levels of corticosterone might tend to decrease the changes in neuropeptide expression of DRG for experimental arthritis.41 Chronic unpredictable stress, which results in a persistent elevation of plasmatic glucocorticoid levels, reduces pain-like behavior.30
Colitis induces calcitonin gene-related peptide expression and Akt activation in rat primary afferent pathways
2009, Experimental NeurologyNeurogenic Mechanisms in Arthritis
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