Elsevier

Neuroscience Letters

Volume 105, Issues 1–2, 23 October 1989, Pages 205-210
Neuroscience Letters

Low-frequency activation of the NMDA receptor system can prevent the induction of LTP

https://doi.org/10.1016/0304-3940(89)90038-4Get rights and content

Abstract

In rat hippocampal slices bathed in Mg2+-free medium tetanic stimulation generally failed to elicit long-term potentiation (LTP) in the Schaffer collateral-commissural pathway. However, LTP could be induced in the same slices following the re-introduction of 1 mM Mg2+. In Mg2+-free medium, LTP could be induced in the presence of 20 μM d-2-amino-5-phosphonovalerate (APV) but was blocked by increasing the APV concentration to 200 μM. The lower concentration of APV is sufficient to prevent N-methyl-d-aspartate (NMDA) receptor activation during low-frequency transmission but not during the tetanus. We suggest therefore, that certain types of activation of the NMDA receptor system can disable the LTP induction mechanism.

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