Elsevier

Neuroscience Letters

Volume 33, Issue 3, 13 December 1982, Pages 323-328
Neuroscience Letters

Nociception is enhanced by the intrathecal injection of 5-methoxy-N,N-dimethyltryptamine in the rat

https://doi.org/10.1016/0304-3940(82)90393-7Get rights and content

Abstract

The effect of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) at the spinal cord level on nociceptive reflexes was tested using the tail-flick assay in rats. 5-MeODMT was injected directly into the spinal subarachnoid space of conscious rats via a permanently indwelling intrathecal cannula. Administration of 100 μg/rat of 5-MeODMT into the thoracic region, using a 4 cm long cannula, reduced the average percent of control reaction time by 14%. The injection of the same dose of 5-MeODMT into the lumbosacral region, via an 8.6 cm long cannula, decreased the average percent of control reaction time by 25%. The ability of 5-MeODMT to mimic the facilitatory (hyperalgesic effect on nociception of similar doses of tryptamine, in contrast to the antinociceptive (analgesic) effect of serotonin, suggests an interaction of 5-MeODMT with tryptaminergic rather than serotonergic receptors in the spinal cord.

References (25)

  • A.A. Boulton et al.

    The subcellular distribution of β-phenylethylamine, p-tyramine and tryptamine in rat brain

    J. Neurochem.

    (1975)
  • F.E. D'Amour et al.

    A method for determining loss of pain sensation

    J. Pharmacol. exp. Ther.

    (1941)
  • Cited by (2)

    View full text