Elsevier

Neurobiology of Aging

Volume 10, Issue 5, September–October 1989, Pages 623-629
Neurobiology of Aging

Review
Novel CNS-directed drug delivery systems in Alzheimer's disease and other neurological disorders

https://doi.org/10.1016/0197-4580(89)90155-3Get rights and content

Abstract

Increasing knowledge of the neurochemical aspects of central nervous system function raises the possibility of treating Alzheimer's disease (AD) and other neurological diseases by the appropriate manipulation of neurotransmitters, neuromodulators, neurohormones or neurotrophic factors. Clinical application of this knowledge may, however, be inhibited by long standing problems with drug delivery to the central nervous system (CNS). Novel, CNS-directed, drug delivery systems might be used to overcome many of these problems. The problems encountered in drug delivery to the brain, present experience with the clinical use of some novel drug delivery systems and the advantages and disadvantages of these systems will be discussed.

References (68)

  • G. Bouvier et al.

    Direct delivery of medication into a brain tumor through multiple chronically implanted catheters

    Neurosurgery

    (1986)
  • H.F. Bradford

    Chemical neurobiology

  • G.A. Brazenor

    Long term intrathecal administration of morphine: A comparison of bolus injection via reservoir with continuous infusion by implanted pump

    Neurosurgery

    (1987)
  • M.W. Brightman et al.

    Junctions between intimately apposed cell membranes in the vertebrate brain

    J. Cell Biol.

    (1969)
  • D.W. Coombs et al.

    Intraspinal narcotic tolerance: Preliminary experience with continuous bupivicaine HCL infusion via implanted infusion device

    Int. J. Artif. Organs

    (1982)
  • D.W. Coombs et al.

    Continuous intrathecal hydromorphone and clonidine for intractable cancer pain

    J. Neurosurg.

    (1986)
  • D.W. Coombs et al.

    Relief of continuous chronic pain by intraspinal narcotics infusion via an implanted reservoir

    JAMA

    (1983)
  • J.R. Cooper et al.

    The biochemical basis of neuropharmacology

  • G.C. Dennis et al.

    Management of intractable pain in cancer patients by implantable morphine infusion systems

    J. Natl. Med. Assoc.

    (1987)
  • D.L. Erickson et al.

    Control of spasticity by implantable continuous flow morphine pump

    Neurosurgery

    (1985)
  • J. Garfield et al.

    Postoperative intracavitary chemotherapy of malignant gliomas

  • S. Gauthier et al.

    Transmitter replacement therapy in Alzheimer's disease using intracerebroventricular infusions of receptor agonists

    Can. J. Neurol. Sci.

    (1986)
  • H.S. Greenberg et al.

    Benefit from and tolerance to continuous intrathecal infusion of morphine for intractable cancer pain

    J. Neurosurg.

    (1982)
  • R.E. Harbaugh

    Brain biopsy in Alzheimer's disease: Surgical technique and indications

    Bull. Clin. Neurosci.

    (1985)
  • R.E. Harbaugh

    Intracranial drug administration in Alzheimer's disease

    Psychopharmacol. Bull.

    (1986)
  • R.E. Harbaugh

    Intracerebroventricular bethanechol chloride administration in Alzheimer's disease

    Ann. NY Acad. Sci.

    (1988)
  • R.E. Harbaugh

    Intracerebroventricular cholinergic drug administration in Alzheimer's disease: Preliminary results of a double blind study

    J. Neurontransm.

    (1987)
  • R.E. Harbaugh

    Multiple chronically implanted catheters (letter)

    Neurosurgery

    (1987)
  • R.E. Harbaugh et al.

    Implanted continuous epidural morphine infusion system: Preliminary report

    J. Neurosurg.

    (1982)
  • R.E. Harbaugh et al.

    Phase I study of intratumoral methotrexate infusion in malignant brain tumors

  • Harbaugh, R.E.; Gonsalves, S.F.; Krogsgaard-Larsen, P.; Schousboe A. Intraventricular administration of anticonvulsant...
  • R.E. Harbaugh et al.

    Preliminary report: Intracranial cholinergic drug infusion in patients with Alzheimer's disease

    Neurosurgery

    (1984)
  • R.E. Harbaugh et al.

    Chronic non-malignant pain: Results at Dartmouth with continuous epidural morphine

  • F. Hefti et al.

    Nerve growth factor and Alzheimer's disease

    Ann. Neurol.

    (1986)
  • Cited by (23)

    View all citing articles on Scopus
    View full text