Changes in lactate dehydrogenase isoenzyme pattern in patients with tumors of the central nervous system

doi:10.1016/0197-0186(93)90004-O

Neurochemistry International

Volume 22, Issue 2, February 1993, Pages 121-124

https://doi.org/10.1016/0197-0186(93)90004-O Get rights and content

Abstract

Lactate dehydrogenase (LDH) isoenzymes were studied in biopsy samples obtained from 100 benign and malignant brain tumors. Diagnosis was confirmed by histopathology. It is observed that all tumors investigated had elevated LDH activity and showed a LDH isoenzyme pattern which is different from that of normal brain. A pronounced cathodal shift was seen in malignant tumors like medulloblastoma, grade 3–4 astrocytomas and neuroblastomas, whereas anodal pattern was seen in benign tumors like grade 1–2 astrocytomas and oligodendrogliomas. Some tumors like meningiomas showed a midzone pattern like increased LDH₃. It was possible to differentiate certain tumors on the basis of LDH isoenzyme pattern like medulloblastomas into differentiated and undifferentiated; craniopharyngiomas into recurring and non-recurring ones. LDH₁/LDH₅ ratio was low (< 1.0) in malignant tumors and high (5.0–14.0) in benign tumors and it was useful in differentiating tumors according to the degree of malignancy and biological behavior. It is observed that both LDH isoenzyme pattern and LDH₁/LDH₅ ratio could be used as an adjuvant to histopathological grading of brain tumors.

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Changes in lactate dehydrogenase isoenzyme pattern in patients with tumors of the central nervous system

Abstract

Cytochemical changes in LDH isoenzymes in human brain tumors

Acta Neurochir.

LDH isoenzymes in CSF in various brain tumors

Neurol. Neurosurg. Psychiat.

Changes in LDH isoenzyme patterns in patients with tumors of CNS

Acta Neurochir.

Standardization of isoenzyme assay with special reference to LDH isoenzyme separation

Clin. Biochem.

Altered LDH isoenzymes in brain tumors

Arch. Neurol.