Research reportIncreased levels of the Kunitz protease inhibitor-containing βAPP mRNAs in rat brain following neurotoxic damage
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Systems Immunology and Infection Microbiology
2021, Systems Immunology and Infection MicrobiologyAmyloid precursor protein revisited: Neuron-specific expression and highly stable nature of soluble derivatives
2012, Journal of Biological ChemistryCitation Excerpt :However, APP, in particular the 751/770 isoforms, have also been reported to be expressed in astrocytes (2, 3, 28–32), One study even stated that the total amount of astroglial APP is 90% higher than neurons (4). In addition, there are numerous studies reporting increased APP expression in reactive astrocytes induced by different insults, such as lesions or injury of the hippocampus (4, 33, 34), heterotopic transplantation (35), cerebral artery occlusion (36), needle stab injury (14), cuprizone intoxication (37), kainic acid-induced neurotoxic damage (38), and exposure to Aβ peptides (39). Increased APP expression in astrocytes was also suggested to contribute to Aβ plaque deposition and AD pathogenesis (4, 40).
Capsaicin promotes the amyloidogenic route of brain amyloid precursor protein processing
2009, Neurochemistry InternationalExpression of APP pathway mRNAs and proteins in Alzheimer's disease
2007, Brain ResearchCitation Excerpt :Dense core plaques, from which formic acid extractable Aβ derives, are frequently associated with local reactive astrocytes. Studies using animal models have demonstrated that elevated levels of APP-KPI were observed in rat cerebral cortex following neurotoxic damage (Sola et al., 1993) (Sola et al., 1993), which was accompanied by elevated GFAP mRNA levels (Lopes et al., 1994). APP-KPI immunoreactivity has been reported to correlate with neuritic plaque density (Zhan et al., 1995).
Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease
2006, American Journal of Human Genetics