Trends in Genetics
ReviewGenesis of the Drosophila peripheral nervous system
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Cited by (262)
2.17 - Evolution of Hair Cells
2020, The Senses: A Comprehensive Reference: Volume 1-7, Second EditionbHLH factors in neurogenesis and neuronal subtype specification
2020, Patterning and Cell Type Specification in the Developing CNS and PNS: Comprehensive Developmental Neuroscience, Second EditionSelf-Organization in Pattern Formation
2019, Developmental CellCitation Excerpt :Where bristles can form is governed by the expression of proneural transcription factors such as Achaete and Scute, which endow cells with the competence to become sensory organ precursor cells (SOPs). SOPs are then selected from among the competent cells through lateral inhibition mediated by Delta ligand and Notch receptor (Ghysen and Dambly-Chaudière, 1989; Simpson, 1990), which antagonizes the activity and expression of the proneural factors through its E(spl)-HLH targets (Delidakis et al., 2014). The pattern of proneural gene expression thus largely prefigures the layout of sensory organs (Campuzano and Modolell, 1992).
Expression of mammalian ASH1 and ASH4 in Drosophila reveals opposing functional roles in neurogenesis
2019, GeneCitation Excerpt :Using insect bristles and mammalian hair as a phenotypic marker is a method for making comparative studies between the two systems, but the structures actually have many differences. Drosophila bristles are made of chitin and are part of the peripheral nervous system, with each bristle being connected with a neuron (Ghysen and Dambly-Chaudiere, 1989). The temporal and spatial expression of AS-C helps generate the peripheral nervous system in conjunction with species specific bristle patterning across the Diptera (Gruber et al., 2007; Garcíabellido and de Celis, 2009).
A newly identified type of attachment cell is critical for normal patterning of chordotonal neurons
2016, Developmental BiologyCitation Excerpt :Each of the five scolopidia that constitute the LCh5 organ contains a sensory unit composed of a neuron and a scolopale cell, and two accessory cells between which the sensory unit is stretched: a cap cell at the dendritic side and a ligament cell at the axonal side of the neuron. The cap and the ligament cells of all five organs are anchored to the cuticle by two cap-attachment (CA) cells (Ghysen and Dambly-Chaudiere, 1989; Matthews et al., 1990) and one ligament-attachment cell (LA), respectively (Inbal et al., 2004) (Fig. 1). The neuron, scolopale, cap, ligament and CA cells of each scolopidium are derived from a single Ato-expressing precursor through four asymmetric cell divisions (Brewster and Bodmer, 1995; Jarman et al., 1993).
Post-translational Control of the Temporal Dynamics of Transcription Factor Activity Regulates Neurogenesis
2016, CellCitation Excerpt :An even smaller subset called basic-Helix-Loop-Helix (bHLH) proneural proteins are the key initiators and regulators of generation of neurons from early neural progenitors (Bertrand et al., 2002; Hassan and Bellen, 2000). The Drosophila Achaete-Scute Complex (AS-C) genes are necessary and sufficient for the specification of peripheral nervous system (PNS) sensory organ precursors from neuroectodermal cells (Campuzano and Modolell, 1992; Ghysen and Dambly-Chaudiere, 1989; Jan and Jan, 1994), while the Atonal (Ato) protein (Jarman et al., 1993) is the proneural factor of the fly neural retina (Jarman et al., 1994, 1995). In the mammalian cortex and spinal cord bHLH proneural proteins such as Achaete-Scute homolog 1 (Ash1) and Neurogenin 2 (Ngn2) regulate the proneural transition (Casarosa et al., 1999; Fode et al., 1998; Ma et al., 1998).