Rapid communicationWater deprivation in the rat induces nitric oxide synthase (NOS) gene expression in the hypothalamic paraventricular and supraoptic nuclei
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Cited by (85)
Perinatal exposure to octabromodiphenyl ether mixture, DE-79, alters the vasopressinergic system in adult rats
2020, Toxicology and Applied PharmacologyDistribution of nitric oxide synthase in the rock cavy (Kerodon rupestris) brain I: The diencephalon
2018, Brain ResearchCitation Excerpt :Some of the most potent stimuli for increasing the expression of OXY and VP in those nuclei are the change of the plasmatic osmolarity, the hypovolemia and the hypotension (Cunningham and Sawchenko, 1991; Dunn et al., 1973). The same happens to NO in PV and SO (Kadowaki et al., 1994; Ueta et al., 1995; Ueta et al., 1998; Villar et al., 1994). The role of NO in VP and OXY secretion is incongruent (Kadekaro, 2004).
Enhanced expression of hypothalamic nitric oxide synthase in rats developmentally exposed to organophosphates
2014, Brain ResearchCitation Excerpt :It has been shown that NO contributes to the control of the basal and modulated release of neurotransmitters and neurohormones acting in the hypothalamus (Affleck et al., 2012; Martins-Pinge et al., 2013; Prast and Philippu, 1992; Stern, 2004). Expectedly, many physiological and pathological conditions that alter the function of the hypothalamus also change the expression of NOS in particular hypothalamic areas (Gadek-Michalska et al., 2012; Heesch et al., 2009; Ueta et al., 1995a, 1995b; Whitaker and Molina, 2013). Organophosphate (OP) insecticides are conventional acetylcholinesterase inhibitors but can induce several long lasting neurochemical, endocrine and cardiovascular alterations through mechanisms unrelated to their primary action (ElMazoudy and Attia, 2012; Meyer et al., 2004; Tait et al., 2009).
Hypertonicity increases NO production to modulate the firing rate of magnocellular neurons of the supraoptic nucleus of rats
2013, NeuroscienceCitation Excerpt :Although hypertonicity itself modulates the electrical activity of magnocellular neurons (Oliet and Bourque, 1993), in the present study we demonstrated that this phenomenon is accompanied by an increase in NO production by the cell itself (Figs. 1 and 2). This result is supported by previous studies showing that after an acute or chronic hypertonic stimulation, markers of nitric oxide synthase, such as NADPH-diaphorase and mRNA levels of this enzyme, are enhanced in the supraoptic nucleus (Summy-Long et al., 1984; Kadowaki et al., 1994; Ueta et al., 1995; Srisawat et al., 2004; Yamova et al., 2007). The increase in the production of NOS in the SON indicates that NO may be involved in the control of the excitability of the MNCs, particularly in situations where the plasma osmolality is compromised.
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