Serum lipid and lipoprotein levels in premature ageing syndromes: total lipodystrophy and Cockayne syndrome

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Abstract

Serum lipids and lipoproteins were investigated in two girls who suffered from total lipodystrophy, in their family members, and in two brothers suffering from Cockayne syndrome. Hyperlipoproteinemia type IIb (Fredrickson) was detected in one case with total lipodystrophy. Very low levels of serum high density lipoprotein cholesterol (HDL-Ch) were observed in both of total lipodystrophic cases, in most of their first degree relatives, and in one of patients with Cockayne syndrome.

Because total lipodystrophy and the Cockayne syndrome belong to ageing syndromes they can serve as a useful model of premature arteriosclerosis and the defect lipid metabolism.

References (28)

  • E.A. Cockayne

    Dwarfism with retinal atrophy and deafness

    Arch. Dis. Child.

    (1946)
  • J.J. Gilkes et al.

    The premature ageing syndromes. Report of eight cases and description of a new entity named metageria

    Br. J. Dermatol.

    (1974)
  • C.J. Glueck et al.

    Longevity syndromes: familial hypobeta- and familial hyperalpha-lipoproteinaemia

    J. Lab. Clin. Med.

    (1976)
  • C.J. Glueck et al.

    Pediatric victims of unexplained stroke and their families: familial lipid and lipoprotein abnormalities

    Pediatrics

    (1982)
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