Trends in Neurosciences
ReviewInterrelationship between Schwann cell function and extracellular matrix production
References (30)
- et al.
J. Neurol. Sci.
(1973) - et al.
Dev. Biol.
(1982) - et al.
- et al.
Int. Rev. Connect. Tissue Res.
(1981) - et al.
Brain Res.
(1980) Brain Res.
(1976)- et al.
Am. J. Anat.
(1974) - et al.
- et al.
Annu. Rev. Neurosci.
(1981) - et al.
J. Cell Biol.
J. Cell Biol.
J. Cell Biol.
J. Cell Biol.
Cited by (105)
Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury
2017, Cell ReportsCitation Excerpt :The morphological transition from a differentiated Schwann cell into a repair Schwann cell is similar to epithelial-mesenchymal transition (EMT), which has well-known roles in oncogenesis and wound healing (Lamouille et al., 2014). Myelin Schwann cells have previously been likened to epithelial cells (Bunge and Bunge, 1983), as they have a basement membrane and cell polarity, with an abaxonal and adaxonal membrane, and express typical epithelial markers such as E-cadherin, claudins, and polarity proteins such as PAR3 (Chan et al., 2006; Crawford et al., 2008; Table S1). After nerve injury, Schwann cells lose their abaxonal and adaxonal polarity, re-enter the cell cycle, and adopt migratory behavior at the site of injury (Jessen and Mirsky, 2016).
Extracellular matrix components as therapeutics for spinal cord injury
2017, Neuroscience LettersCitation Excerpt :Considering the roles of ECM, rendering the ECM milieu optimum for repair is a legitimate therapeutic approach. This is supported by the unique composition of ECM in regenerative niches within the mature CNS and in peripheral nerves, particularly in Schwann cell basal lamina, which is known to facilitate repair [4]. Considering its ability to promote and sustain stability within the CNS, targeted manipulation of ECM after damage offers a means to elicit tissue repair and functional recovery after SCI.
In Vivo Synthesis of Tissues and Organs
2013, Principles of Tissue Engineering: Fourth EditionBiology of Schwann cells
2013, Handbook of Clinical NeurologyCitation Excerpt :Endoneurial fibroblasts secrete other matrix components and contribute collagen fibrils. As with many facets of Schwann cell biology, the relationship between axonal interaction and basal lamina production is reciprocal and iterative, in that Schwann cells require axonal contact to secrete key basal lamina components (Bunge et al., 1972; Carey et al., 1983; Carey and Todd, 1987) while requiring basal lamina assembly as a prerequisite for subsequent axonal interactions (Bunge and Bunge, 1983; Carey and Todd, 1987; Eldridge et al., 1987; Fernandez-Valle et al., 1993; Podratz et al., 2001). Cells interact with basal lamina components via extracellular matrix receptors on their surface, and these interactions promote signaling cascades that are essential for cell orientation and function.
Emerging rules for inducing organ regeneration
2013, BiomaterialsCitation Excerpt :In sharp topographic distinction, in a peripheral nerve, the approximately 5000 nerve fibers (rat sciatic nerve), each considered a distinct organ, are bundled together in cylindrical symmetry. Studies by neuroscientists in a developmental context [20] have led to the widely accepted identification of similarities between keratinocytes in skin and Schwann cells in nerve fibers. Among the arguments used by these authors [20] is the ability of Schwann cells to synthesize the basement membrane to which they are attached, a property shared by keratinocytes in skin.