The involvement of specific anti myelin basic protein antibody-forming cells in multiple sclerosis immunopathology
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Cited by (42)
Pathology of multiple sclerosis and related inflammatory demyelinating diseases
2014, Handbook of Clinical NeurologyCitation Excerpt :Their biologic relevance is so far undetermined. A single, so far unconfirmed, study used biotinylated myelin basic protein (MBP) as a tool to identify MBP antibody-producing B cells in MS lesions and the authors described that up to 50% of local plasma cells in the lesions produce MBP-reactive autoantibodies (Gerritse et al., 1994). This seems to be an unrealistically high percentage, considering both the multitude of potential autoantigens and the difficulties in unequivocally identifying autoantibodies in the cerebrospinal fluid of MS patients.
Autoantigen induced clonal expansion in immortalized B cells from the peripheral blood of multiple sclerosis patients
2013, Journal of NeuroimmunologyCitation Excerpt :The most important evidence for the involvement of B cells comes from the finding of oligoclonal immunoglobulin G (IgG) bands (OCBs) in the cerebrospinal fluid (CSF) of more than 90% of MS patients (Kabat et al., 1948; Cole et al., 1998). Further, the presence of B cells, plasma cells, complement, myelin-specific antibodies and B cell cytokines was reported in chronic MS lesions (Esiri, 1977; Gerritse et al., 1994; Genain et al., 1999; Archelos et al., 2000; Cross et al., 2001; Krumbholz et al., 2005; Ziemssen and Ziemssen, 2005). The most frequent (approximately 58%) lesion type in MS patients is the pattern II demyelinating lesion, characterized by immunoglobulin (Ig) deposits and involvement of the complement system (Lucchinetti et al., 2000).
B and T cells in the brains of autoimmune mice
2004, Journal of NeuroimmunologyCellular Damage and Repair in Multiple Sclerosis
2004, Myelin Biology and Disorders