Murine tumor necrosis factor alpha is transported from blood to brain in the mouse
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2022, iScienceCitation Excerpt :The BBB cells (endothelial cells, pericytes, and astrocytes) respond to signals originating from either side by changes in permeability, transport, and secretory functions (Cunningham et al., 2009; Erickson and Banks, 2018; Verma et al., 2006). It has been previously shown that TNF-α crosses the intact BBB by a receptor-mediated transport system, upregulated by CNS trauma and inflammation (Gutierrez et al., 1993; Pan and Kastin, 2002; Pan et al., 2003a). Free traffic of radioactively labeled TNF-α from blood to brain and cerebrospinal fluid (CSF) has been shown in mice (Gutierrez et al., 1993; Pan et al., 1997), as well as in monolayers of cultured cerebral microvessel endothelial cells (Pan et al., 2003b).
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