Research paper
No association with germline T cell receptor β-chain gene alleles or haplotypes in Swedish patients with multiple sclerosis

https://doi.org/10.1016/0165-5728(91)90006-SGet rights and content

Abstract

Multiple sclerosis (MS) has been reported to be associated with restriction fragment length polymorphism (RFLP)-defined alleles of the T cell receptor (TcR) α- and β-chain genes. One hundred patients with MS, 23 with primarily chronic progressive MS and 77 with relapsing/remmitting MS, as well as 100 controls were investigated with RFLP analysis of the Vβ8, Vβ11 and Cβ TCR gene segments. No association was found with allelic patterns or, contrary to a previous report (Beall et al. (1989) J. Neuroimmunol. 21, 59–66), TcR β-chain gene haplotypes. Subgrouping of patients according to clinical form of disease or MS-associated HLA class II alleles also failed to show associations to TcR β-chain RFLPs. Thus, our results fail to confirm that TcR β-chain gene haplotypes confer susceptibility to MS.

References (39)

  • B. Freimark et al.

    T-cell antigen receptor gene expression in Sjögren's syndrome

    Arthritis Rheum.

    (1987)
  • M. Goldstein et al.

    The T cell receptor beta chain and systemic lupus erythematosus

    Clin. Res.

    (1987)
  • D.G. Haegert et al.

    HLA-DRβ, -DQα and -DQβ restriction fragment length polymorphisms in multiple sclerosis

    J. Neurosci. Res.

    (1989)
  • N. Harindranath et al.

    Allotypes of the constant region of the rabbit T cell receptor β-2 chain

    J. Immunol.

    (1989)
  • H.-Z. Ho et al.

    HLA-linked and unlinked determinants of multiple sclerosis

    Immunogenetics

    (1982)
  • M.L. Hoover et al.

    HLA-DQ and T-cell receptor genes in insulin-dependent diabetes mellitus

  • E.C. Jazwinska et al.

    Gm typing by immunoglobulin heavy-chain gene RFLP analysis

    Am. J. Hum. Genet.

    (1988)
  • M.J. Johnson et al.

    Ig gamma restriction fragment length polymorphisms indicate an ancient separation of caucasian haplotypes

    Am. J. Hum. Genet.

    (1986)
  • N. Kimura et al.

    Sequences and diversity of human T cell receptor β chain variable region genes

    J. Exp. Med.

    (1986)
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