Mutation Research/Environmental Mutagenesis and Related Subjects
Micronucleated erythrocytes as an assay to assess actions by physical and chemical genotoxic agents in Clarias gariepinus
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Cited by (53)
Aquatic ecotoxicology of anticancer drugs: A systematic review
2021, Science of the Total EnvironmentCitation Excerpt :Finally, in Nakano et al. (2003) study, mitomycin C elicited offspring malformations and germ cells mutations at concentrations ranging between 1 and 100 μM in mollusca. It has also induced dose and time-dependent micronuclei formation in fish with concentrations ranging between 0.25 and 10 mg/kg (Bahari et al., 1994; Das and Nanda, 1986; Winter et al., 2007). Tyrosine kinase inhibitors block the receptor tyrosine kinases that promote cell division and survival (Gustafson and Bailey, 2019).
Assessment of the cytotoxic and mutagenic potential of the Jialu River and adjacent groundwater using human-hamster hybrid cells
2018, Journal of Environmental Sciences (China)Citation Excerpt :We reasoned therefore that assessing the overall effects of these compounds will be facilitated by investigating the cytotoxicity and genotoxicity of the river water and its adjacent groundwater. Numerous in vivo tests on the genotoxicity of water samples were conducted, particularly using indigenous aquatic organisms such as fish (Bahari et al., 1994; Alsabti and Metcalfe, 1995; Minissi et al., 1996), sea urchins (Hose et al., 1983), mussels (Ericson et al., 2002; Klobucar et al., 2003), oysters (Burgeot et al., 1995), newts (Jaylet et al., 1986; Fernandez et al., 1993), and marine worms (Jha et al., 1995). Nevertheless, because of the insensitivity of aquatic organisms to genotoxic compounds and complexities involved in manipulating these organisms in the laboratory, the application of in vitro genotoxic tests of water samples is more helpful for investigating the presence and distribution of genotoxins (Ohe et al., 1993; Eckl, 1995; Schnurstein and Braunbeck, 2001).
Sensitivity of medaka (Oryzias latipes) to 4-nonylphenol subacute exposure; erythrocyte alterations and apoptosis
2018, Environmental Toxicology and PharmacologyCitation Excerpt :Fish erythrocytes are favored because the frequency of alterations in both cytoplasm and nuclei can be a marker of cytotoxicity, genotoxicity, hemotoxicity, and oxidative stress (Bushra et al., 2002; Gomes et al., 2015; Joshi et al., 2002; Mekkawy et al., 2011; Sayed et al., 2017; Sayed et al., 2016c). The frequency of alterations in fish erythrocytes, the induction of MN, and their apoptosis have been studied after exposure UVA, pesticides, hydrocarbons, and toxins (Bahari et al., 1994; Bombail et al., 2001; Bushra et al., 2002; Mekkawy et al., 2011; Sayed et al., 2016c; Talapatra and Banerjee, 2007). Apoptosis is associated with signs of abnormal cell morphology including cell shrinkage, membrane blebbing and chromatin condensation (Cavas et al., 2005; Murakawa et al., 2001; Sayed and Hamed, 2017; Talapatra and Banerjee, 2007).
Assessment of endosulfan induced genotoxicity and mutagenicity manifested by oxidative stress pathways in freshwater cyprinid fish crucian carp (Carassius carassius L.)
2015, ChemosphereCitation Excerpt :Earlier, it has been emphasized that exposure of fish to genotoxic chemicals, for various interval of time, by the respiratory route following the absorption of chemicals through gill epithelium could be occurred (Rishi and Grewal, 1995; Farah et al., 2006). Our results of MN are in agreement with some earlier studies (Bahari et al., 1994; Ali et al., 2008). The frequency of CA observed in C. carassius after exposure to different concentrations of test chemical and standard genotoxic agent, cyclophosphamide, were significantly (p < 0.05) higher when compared to the negative control (Table 3), at all the exposure durations.
Effects of 4-nonylphenol on blood cells of the African catfish Clarias gariepinus (Burchell, 1822)
2011, Tissue and CellCitation Excerpt :The study of micronucleus test and abnormal erythrocytes morphology in fishes by various chemicals have been reported (Grisolia and Starling, 2001; Ferraro et al., 2004; Talapatra and Banerjee, 2007). Fish erythrocytes are especially favoured for micronucleus test (Bushra et al., 2002) and its feasibility has already been established in Clarias gariepinus (Bahari et al., 1994). It was stated by many authors that abnormal nuclear morphology is an indicator of genotoxic damage in fish (Bombail et al., 2001; Talapatra and Banerjee, 2007).
Ultraviolet radiation-induced genotoxic effects in the broad-snouted caiman, Caiman latirostris
2010, Mutation Research - Genetic Toxicology and Environmental Mutagenesis