Cell
ArticleGroucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins
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2020, CellCitation Excerpt :These repressor domains have distinct dynamics of silencing and memory: the first domain (AAs 341–420) featured slow silencing but strong memory, while the second domain (AAs 2,381–2,460), featured rapid silencing but weak memory (Figure 6G). Since some known repressors are much shorter than 80 AAs (Drueppel et al., 2004; Fisher et al., 1996; Han and Manley, 1993; Paroush et al., 1994), we attempted to identify the minimal necessary sequence for repressor function in each independent domain by examining the overlap in all of the tiles covering a protein region and defining the sequence present in all of the repressive tiles (Figure 6H). Using this approach, we generated 2 candidate minimized effector domains for MGA: the 10-AA sequence MGA[381–390] and the 30 amino acid sequence MGA[2,431–2,460]; both overlapped conserved regions and efficiently silenced the reporter (Figure 6I).
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2020, Insect Biochemistry and Molecular BiologyTranscriptional repression of endogenous genes in BmE cells using CRISPRi system
2019, Insect Biochemistry and Molecular BiologyCitation Excerpt :In this study, we performed dCas9-mediated transcriptional repression in BmE cells. We tested constructs of dCas9 fused with three other repressors, including the mSin3A interaction domain (SID) (Ayer et al., 1995; Eilers et al., 1999), the hairy domain (Fisher and Caudy, 1998; Paroush, 1994) and the ERF repressor domain (ERD) (Ohta et al., 2001; Sgouras et al., 1995). Our results should provide a foundation for dCas9-mediated transcriptional regulation in B. mori, while expanding the range of application for CRISPR/Cas9.
Division of Labor: Roles of Groucho and CtBP in Notch-Mediated Lateral Inhibition that Controls Intestinal Stem Cell Differentiation in Drosophila
2019, Stem Cell ReportsCitation Excerpt :CtBP is typically thought of as a short-range co-repressor and Gro is thought of as a long-range co-repressor, so perhaps the separate or combinatory use of these two co-repressors allows for considerable flexibility to control transcriptional activity (Courey and Jia, 2001). In addition, it is known that Gro, but not CtBP, functions as a co-repressor of the major Notch transcriptional targets, the Enhancer of (spl)-complex (E(spl)-C) proteins (Paroush et al., 1994). These observations from previous studies collectively show that Gro and CtBP can function together or separately with different co-factors to regulate gene transcription.
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