Cell
ArticleA kinesin-like protein required for distributive chromosome segregation in Drosophila
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New insights into the mechanism for chromosome alignment in metaphase
2013, International Review of Cell and Molecular BiologyCitation Excerpt :The polar ejection force at chromosome arms as a result of the interaction between chromokinesins and spindle MTs could balance poleward kinetochore forces, and thus, influence chromosome congression and oscillation. Drosophila Nod, the first identified chromokinesin, is required for proper alignment and segregation of meiotic chromosomes (Afshar et al., 1995; Zhang et al., 1990). Immunodepletion of the Xenopus homolog, Kid, from egg extracts results in congression defects and metaphase chromosome misalignment (Antonio et al., 2000; Funabiki and Murray, 2000).
Kinesin structure and biochemistry
2012, Comprehensive BiophysicsHow kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays
2010, Seminars in Cell and Developmental BiologyATPase Cycle of the Nonmotile Kinesin NOD Allows Microtubule End Tracking and Drives Chromosome Movement
2009, CellCitation Excerpt :Specifically, the protein product of the nod+ gene is required for the proper segregation of nonexchange chromosomes without impairing the segregation of chromosomes that do undergo meiotic exchange via crossing over. NOD is a chromokinesin-like protein from the kinesin-10 family that is localized along the arms of meiotic chromosomes (Afshar et al., 1995; Zhang et al., 1990). NOD consists of an N-terminal kinesin-like catalytic domain and a C terminus that contains two types of DNA binding motifs (Cui and Hawley, 2005).
How kinesins walk, assemble and transport: A birds-eye-view of some unresolved questions
2006, Physica A: Statistical Mechanics and its ApplicationsExpression of meiotic genes in the germline progenitors of Drosophila embryos
2006, Gene Expression Patterns