Cell
Definition of multiple, functionally distinct TATA elements, one of which is a target in the hsp70 promoter for E1A regulation
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Cited by (208)
Multiple domains in the 50 kDa form of E4F1 regulate promoter-specific repression and E1A trans-activation
2020, GeneCitation Excerpt :Perhaps p50E4F1 provides a remedy to such effects that would otherwise reduce PIC nucleation and/or re-initiation rates and thus diminish E1A-induced high-level E4 gene expression. It is noteworthy that in some contexts, substitution of non-canonical TATA box sequences in several other promoters also reduces their trans-activation by E1A (Nicholas and Nevins, 1991; Simon et al., 1988; Simon et al., 1990). In addition to TATA box sequences, a second notable difference between the E4 and pG5 promoters are binding sites for TFIIB, a TBP-interacting general transcription factor that plays an integral role in RNA polymerase II recruitment into the PIC and polymerase release from the complex to permit transcript elongation (Deng and Roberts, 2007; Juven-Gershon and Kadonaga, 2010; Thomas and Chiang, 2006).
Core promoter-specific gene regulation: TATA box selectivity and Initiator-dependent bi-directionality of serum response factor-activated transcription
2016, Biochimica et Biophysica Acta - Gene Regulatory MechanismsCitation Excerpt :However, enhancers and activators can also differentially stimulate canonical TFIID-dependent transcription in a core promoter-dependent manner. Early observations showed that different TATA box sequences have different abilities to convey the activating signals of certain enhancers and activators in mammalian cells [34,35] and in yeast [36–38]. The activation domains of VP16 and SP1 fused to the yeast GAL4 DNA-binding domain were also reported to have different core promoter preferences in mammalian cells, although no strict core promoter selectivity was observed since both VP16 and SP1 could significantly activate all core promoter types tested [39].
New problems in RNA polymerase II transcription initiation: Matching the diversity of core promoters with a variety of promoter recognition factors
2007, Journal of Biological ChemistryCitation Excerpt :Analysis of molecular interactions between activator proteins and core promoter context-dependent PICs may argue for a model in which the core promoter is involved in processing information received on the cis-regulatory level of a gene. For example, different TATA box-containing promoters respond differentially to activators, suggesting that they do not bind the same TFIID and/or PIC complexes (65, 66). c-Fos and Elf-1 differentially activate transcription from TATA- and INR-containing core promoters (67, 68), whereas optimal induction by papilloma virus E2 and the artificial Gal-VP16 activator requires both TATA and INR elements (69).
Specific activation of the human HSP70 promoter by copper sulfate in mosaic transgenic zebrafish
2006, Journal of BiotechnologyNon-optimal TATA elements exhibit diverse mechanistic consequences
2006, Journal of Biological ChemistryCitation Excerpt :Taken together, these studies suggest that the TBP-DNA complex may exist in different structural contexts for variant sequences, and this context may also impact downstream steps in the transcription process. Because variant TATA elements play a fundamental role in the proper expression of many eukaryotic genes (9, 10, 21, 24), it is essential to determine the mechanisms underlying differential levels of transcription from varying TATA elements. To further explore the role of sequence variation in TATA element function, the in vivo and in vitro properties of a panel of substituted elements were characterized (summarized in Table 3).
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Present address: Howard Hughes Medical Institute, Department of Microbiology-Immunology, Duke University Medical Center, P. O. Box 3054 Durham, North Carolina 27710.