Original articleCharacterization of the mononuclear cell infiltrate in atopic dermatitis using monoclonal antibodies☆
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Skin barrier defects in atopic dermatitis: From old idea to new opportunity
2022, Allergology InternationalCitation Excerpt :Rasch referred to AD as Besnier's prurigo in 1914,2,3 and made the observation that even the non-eczematous skin was xerotic. Histologic analysis of AD lesions documented changes in both the epidermis (acanthosis) and dermis (inflammatory infiltrates characterized by mononuclear cells and eosinophils) which were also observed in nonlesional (NL) skin.11–15 It was not until 1978, when TEWL measurements were first performed on both lesional (L) and NL skin of AD patients that the scientific community began to accept that AD patients had a skin barrier defect and that this observed throughout the skin integument.16
Staphylococcus aureus–derived lipoteichoic acid induces temporary T-cell paralysis independent of Toll-like receptor 2
2016, Journal of Allergy and Clinical ImmunologyNew pathogenic and therapeutic paradigms in atopic dermatitis
2015, CytokineCitation Excerpt :While Th1-mediated inflammation aims to fight infections through its main cytokine, IFN-γ, Th2-associated cytokines, such as IL-4, IL-5, and IL-13, are involved in allergic responses and mediate IgE class-switching, among other functions [80]. AD is associated with Th2 expansion in skin [81]. The Th2 cytokines have specific effects on the epidermis, including suppression of keratinocyte differentiation and AMP production, which contribute to the AD skin phenotype [15,82].
Deciphering the complexities of atopic dermatitis: Shifting paradigms in treatment approaches
2014, Journal of Allergy and Clinical ImmunologyIL-10 suppresses IL-17-mediated dermal inflammation and reduces the systemic burden of Vaccinia virus in a mouse model of eczema vaccinatum
2014, Clinical ImmunologyCitation Excerpt :It occurs in allergy-prone “atopic” individuals who are predisposed to the production of IgE antibodies directed against aeroallergens and foods. Acute AD lesions are infiltrated with CD4+ Th2 cells, which secrete predominately IL-4, IL-5 and IL-13 [1]. In chronic AD, interferon (IFN)-γ producing Th1 and IL-22 producing cells arise as well and are probably kept in check by the Th2 cells which persist [2].
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Supported by U.S.P.H.S. grants AM-16392, AI-05877, and CA-29061, HL-18646, and by grants from the Hood Foundation and the Rorer Co.
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R. S. G. is the recipient of Allergic Diseases Academic Award No. 1 KO7 AI 00440-01.