Mechanism of the body weight increase induced by systemic sulpiride
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TIDAL WAVES: Network mechanisms in the neuroendocrine control of prolactin release
2014, Frontiers in NeuroendocrinologyCitation Excerpt :Pathological hyperprolactinaemia causes effects that mirror the physiological actions of the hormone but are de-correlated from reproductive state. These include gynecomastia and galactorrhea (see Haddad and Wieck, 2004), infertility through oligo- or amenorrhea, (Delvoye et al., 1978; Greer et al., 1980; Smith et al., 2002; see Caufriez, 1985), diminished sexual drive, anorgasmia and ejaculatory dysfunction (Ghadirian et al., 1982; Buvat et al., 1985; Serretti and Chiesa, 2011; see Bolyakov and Paduch, 2011), obesity and metabolic syndrome (Parada et al., 1989; see Ben-Jonathan et al., 2006) as well as osteoporosis due to sex hormone imbalance (Klibanski et al., 1980). For an extensive review on the biology and actions of prolactin, the reader is referred to Freeman et al. (2000).
Lactational exposure to sulpiride: Assessment of maternal care and reproductive and behavioral parameters of male rat pups
2013, Physiology and BehaviorCitation Excerpt :In our study, SUL did not alter weight and food intake in dams during lactation. Although increased body weight was described in non-pregnant female rats [37,38], we believe that the lack of SUL-induced increase in body weight observed in this study with lactating dams is explained by the tremendous energy investment during lactation [39]. Mesolimbic and striatal dopaminergic pathways are thought to influence motor function such that DA receptor agonists stimulate and antagonists inhibit motor activity [25].
Metabolic side effects of antipsychotic drug treatment - pharmacological mechanisms
2010, Pharmacology and TherapeuticsDistinct neurobehavioral consequences of prenatal exposure to sulpiride (SUL) and risperidone (RIS) in rats
2008, Progress in Neuro-Psychopharmacology and Biological PsychiatryLithium increases gastrointestinal tract weight of male or female rats but it increases body weight only in females
2008, Progress in Neuro-Psychopharmacology and Biological PsychiatryPharmacogenetics of antipsychotic-induced weight gain
2004, Pharmacological Research