Brief communication
Effect of calorie restriction on the production and responsiveness to interleukin 2 in (NZB × NZW)F1 mice

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Abstract

Calorie restriction preserves the immunologic functions of the autoimmune prone B/W mice and prolongs their life. B/W mice fed normal calories were deficient in production of Interleukin 2 (IL-2) and in responses to exogenous IL-2 after 5 months of age. Calorie restriction leads to the preservation of IL-2 production in the spleen cells of these animals. Furthermore, these calorie-restricted mice responded vigorously to exogenous IL-2 in the thymocyte proliferation assay while mice fed a normal calorie diet lost much of the ability of their thymocytes to respond to IL-2. Whether calorie restriction in preserving the immune function of B/W mice involves IL-2 production and/or IL-2 response requires further analysis.

References (26)

  • S. Safai-Kutti et al.

    Clin. Immunol. Immunopathol.

    (1980)
  • K.A. Smith

    Immunol. Rev.

    (1980)
  • S. Izui et al.

    J. Immunol.

    (1978)
  • H.M. Moutsopoulos et al.

    J. Immunol.

    (1977)
  • P.W. Kincade et al.
  • D.R. Barthold et al.

    J. Immunol.

    (1974)
  • N.L. Gerber et al.

    J. Immunol.

    (1974)
  • R.S. Krakauer et al.

    J. Exp. Med.

    (1976)
  • T. Shirai et al.
  • T.B. Smith et al.

    J. Immunol.

    (1978)
  • L.H. Glimcher et al.

    J. Immunol.

    (1980)
  • B.S. Andrews et al.

    J. Exp. Med.

    (1978)
  • P.S. Friend et al.

    Lab. Invest.

    (1978)
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