The last mitoses of the human fibroblast proliferative life span, physiopathologic implications
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The interphase mammalian chromosome as a structural system based on tensegrity
2016, Journal of Theoretical BiologyCitation Excerpt :Thus considering that in a given species each chromosome DNA sequence is common to all cell types, the differential responsible for this cell type-specificity of the NHOS must lay on the properties of the NM as there is ample evidence of diverse cell type-specific NM proteins (Dent et al., 2010; Stuurman et al., 1990) that may constitute alternative options for DNA–NM interactions. Moreover, the highly-packed constitutive heterochromatin decays with time into less condensed states (Macieira-Coelho, 1995; Villeponteau, 1997) so that formerly hidden DNA sequences become exposed and so able to interact with the NM, thus contributing to the modification of the NHOS in time. In fully condensed mitotic chromosomes it has been observed the presence of a residual protein-rich scaffold after removal of chromatin proteins and digestion of DNA (Adolph et al., 1977).
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