Brain-reactive antibodies in sera of aging non-human primates

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Abstract

Previous studies in our laboratory demonstrated an age-related increase in the brain-reactive antibodies in sera of aging mice. The present paper deals with the study of brain-reactive antibodies in sera of non-human primates (Macaca namestrina) of three age groups (4, 10 and 20 years) by an indirect immunofluorescence method. The results indicated a progressive increase in the serum levels of these antibodies with advancing age. Since all three age groups examined demonstrated brain-reactive antibodies in sera, the age of onset of these antibodies could not be determined in these animals. It has been suggested that the formation of these antibodies could be evidence of autoimmune reactions which might play a significant role in neuronal degeneration during aging.

References (52)

  • K. Nandy

    Brain-reactive antibodies in mouse serum as a function of age

    J. Gerontol.

    (1972)
  • K. Nandy et al.

    Specificity of brain-reactive antibodies in serum in old mice

    J. Gerontol.

    (1975)
  • W. Andrew

    The Anatomy of Aging in Man and Animals

    (1971)
  • H. Brody

    Organization cerebral cortex

  • H. Brody et al.

    Anatomical changes in the nervous system

  • J.A.N. Corsellis

    Some observations on the Purkinje cell population and on brain volume in human aging

  • R.S. Ellis

    A preliminary quantitative study of Purkinje cells in normal, subnormal and senescent human cerebella

    J. Comp. Neurol.

    (1919)
  • R.S. Ellis

    Norms for some structural changes in the human cerebellum from birth to age

    J. Comp. Neurol.

    (1920–1921)
  • T. Inukai

    On the loss of Purkinje cells with advancing age from cerebellar cortex of albino rat

    J. Comp. Neurol.

    (1928)
  • B.E. Tomlinson et al.

    Some quantitative cerebral findings in normal and demented old people

  • R.D. Terry

    Senile dementia

  • C.R. Ingram et al.

    Significance of an aging-linked neuron binding gamma-globulin fraction of human sera

    J. Gerontol.

    (1974)
  • K. Nandy

    Immune reactions in aging brain and senile dementia

  • K. Nandy

    Brain-reactive antibodies in aging and senile dementia

  • R.G. Heath et al.

    Schizophrenia as an immunologic disorder

    Arch. Gen Psychiatry

    (1967)
  • A. Motycka et al.

    Autoantibodies and brain ischaemia topography

    Cas. Lek. Cesk.

    (1975)
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