Elsevier

Human Pathology

Volume 26, Issue 8, August 1995, Pages 925-928
Human Pathology

Case study
Intrasellar neuronal choristoma associated with growth hormone-producing pituitary adenoma containing amyloid deposits

https://doi.org/10.1016/0046-8177(95)90018-7Get rights and content

Abstract

The histological, immunocytochemical, and ultrastructural features of an intrasellar neuronal choristoma associated with pituitary growth hormone (GH)-producing adenoma are reported. hnmunohistochemistry studies and electron microscopy examination showed the adenoma cells to be positive for GH but negative for prolactin, and the neurons of the choristoma to have GH-releasing factor (GRF) neurosecretory activity. The adenoma also had many amyloid deposits in its extracellular space immunoreactive to GRF. This is the first report of the tumor containing amyloid deposits.

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