Productive infection of CD4+ cells by selected hiv strains is not inhibited by Anti-CD4 monoclonal antibodies
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Cited by (64)
5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series
2004, Bioorganic and Medicinal Chemistry LettersIsolation and NMR characterization of rosacelose, a novel sulfated polysaccharide from the sponge Mixylla rosacea
2001, Carbohydrate ResearchCitation Excerpt :The NOESY spectra were acquired with mixing times of 25, 50 and 100 ms, 256 scans/t1 value and t1max=37.3 ms. The NMR data were processed on a Silicon Graphic Indigo2 workstation using uxnmr software. Rosacelose (1) has been evaluated for its potential antiviral activity against HIV-1 at Campus Universitaire de Luminy, Marseille, France by Dr J.C. Chermann, by meaning the efficiency of the substrate to inhibit syncytia formation after HIV infection of MT4 cell line, as described previously.43,44 The experimental IC50 value was 5 μg/mL.
Use of proline bioisosteres in potential HIV protease inhibitors: Phenylalanine-2-thiophenoxy-3-pyrrolidinone: Synthesis and anti-HIV evaluation
2000, Bioorganic and Medicinal Chemistry LettersDragmacidin F: A new antiviral bromoindole alkaloid from the mediterranean sponge Halicortex sp.
2000, TetrahedronCitation Excerpt :The activity was expressed as antiviral effective concentration that achieved 50% protection (EC50) of virus-infected cells from the HSV-induced destruction.17,18 Anti HIV-1 activity was monitored by the efficiency of the drug compound to inhibit syncytia formation after HIV-infection of MT4, as described elsewhere.19,20 The inhibitory concentration of drug compound was expressed as the concentration that caused 50% inhibition of syncytia formation (EC50) without direct toxicity for the cells.
New anti-HIV derivatives: Synthesis and antiviral evaluation
2000, Bioorganic and Medicinal Chemistry