Elsevier

Virology

Volume 7, Issue 4, April 1959, Pages 438-448
Virology

The effect of herpes virus on HeLa cells dividing parasynchronously☆

https://doi.org/10.1016/0042-6822(59)90072-8Get rights and content

Abstract

HeLa cells dividing parasynchronously have been used to study the effect of the HFEM strain of herpes virus upon mitosis.

Mitosis of the HeLa cells is inhibited, and this inhibition is prevented by serum containing virus neutralizing antibody. The damage to mitosis occurs rapidly relative to the cycle of virus growth, probably less than 1 hour after virus adsorption. Virus particles which adsorb to, but do not infect, the HeLa cells fail to inhibit mitosis. Similar rates of virus growth were found in both synchronously and asynchronously dividing cells when the former were infected 7 hours before expected division.

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☆

This work was carried out with support from the Medical Research Council.

2

Present address: Department of Virology, University of Glasgow.

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