Elsevier

Toxicon

Volume 9, Issue 3, July 1971, Pages 265-269
Toxicon

Effect of Latrodectus mactans tredecimguttatus venom on sympathetic ganglion isolated in vitro

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Abstract

The effect of Latrodectus venom (L.V.) on the function of the superior cervical ganglion of the rat, isolated in vitro, has been studied. This venom promptly depresses the postganglionic action potentials evoked by preganglionic stimulation, while it elicits discharges of asynchronous action potentials from the unstimulated ganglion. Previous curarization effectively interferes with the production of these discharges. When unstimulated ganglion (previously incubated with H3-choline for 2 hr of repetitive activity) was treated with L.V., a 50 per cent decrease in its labelled acetylcholine content (relative to the control ganglion) was observed

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This research was supported by the Consiglio Nazionale delle Ricerche (Contract No. 69.01669)

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