Symposium: Correlation between Morphologic and Functional Changes Induced by XenobioticsThe relationship between cellular ion deregulation and acute and chronic toxicity☆
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L-Carnitine activates calcium signaling in human osteoblasts
2018, Journal of Functional FoodsCitation Excerpt :To establish whether L-C directly affects mitochondria, an important calcium store in osteoblasts (Martin & Matthews, 1970), hOBs were exposed to the combined administration of CCCP, a mitochondrial uncoupler with Ca2+ mobilization functions, (Pan et al., 2006), and Tg, after the response to L-C. Under this experimental condition, any further increase in the [Ca2+]i was detected in hOBs (Fig. 6A, Table 1). The subsequent addition of Ionomycin, acting both as calcium ionophore and as an activator of residual stores (Trump, Berezesky, Smith, Phelps, & Elliget, 1989), produced only some sporadic and weak [Ca2+]i increments (Fig. 6A). The pre-treatment of hOBs with the combination of Tg, CCCP and Ionomycin, was followed by a lack of the L-C induced [Ca2+]i rise (Fig. 6B).
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This is contribution No. 2626 from the Cellular Pathobiology Laboratory. Supported by NIH AM15440 and NIH 51000-78.