Stereoselective synthesis of 9β-hydroxytaxanes via reduction with samarium diiodide
Reaction of paclitaxel with samarium diiodide yielded 10-deacetyl-9β-hydroxypaclitaxel (1). When docetaxel was subjected to the same reaction conditions the corresponding 9β-hydroxydocetaxel (2) and 10-dehydroxy-9β-hydroxydocetaxel (3) were isolated. Compounds 2 and 3 displayed cytotoxicities against B16 melanoma cells comparable to paclitaxel.
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