Therapeutic reviewSystemic antiviral drugs used in ophthalmology☆
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2019, Materials Science and Engineering CCitation Excerpt :The advantage of antiangiogenic therapy is its potential to preserve the function of retinal tissue while directly targeting the neovascular complexes. The antiangiogenic drugs that are currently known as effective are: monoclonal antibodies that target specific molecular sites; bevacizumab (Avastin) - the “parent” molecule of ranibizumab, a full-length monoclonal antibody, corticosteroids (intravitreal triamcinolone acetonide, dexamethasone, fluocinolone acetonide, anecortave acetate) [4,5]. Bevacizumab (BEV) was authorized in 2004 for the chemotherapy treatment of metastatic colorectal cancer [6], in 2006 for cell lung cancer [7], in 2009 for glioblastoma multiform [8].
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2009, American Journal of OphthalmologyCitation Excerpt :Another reason to consider famciclovir in the treatment of ARN is the emergence of cases of acyclovir-resistant ARN.9,25,26 The 3 most common mechanisms of herpes virus resistance to acyclovir are loss of thymidine kinase activity, altered thymidine kinase substrate specificity, and mutation of the viral DNA polymerase.27 Famciclovir/penciclovir may be effective in the treatment of some cases of acyclovir-resistant VZV.9
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This work was supported in part by an unrestricted grant from Research to Prevent Blindness, New York, NY.